Read Advances in Experimental Medicine and Biology, Volume 640: Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease

Advances in Experimental Medicine and Biology, Volume 640: Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease

Alexander B. Sigalov

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Description:Multichain Immune Recognition Receptors (MIRRs) represent a family of surface receptors expressed on different cells of the hematopoetic system and function to transduce signals leading to a variety of biologic responses. These receptors share common structural features, including extracellular ligand-binding domains and intracellular signaling domains carried on separate subunits. Another important feature linking members of the MIRR family is the presence of one or more copies of a cytoplasmic structural module termed the immunoreceptor tyrosine-based activation motif (ITAM). ITAMs consist of conserved sequences of amino acids that contain two appropriately spaced tyrosines (YxxL/Ix6-8YxxL/I; where x denotes non-conserved residues). Following receptor engagement, phosphorylation of ITAM tyrosine residues represents one of the earliest events in the signaling cascade. Although the MIRR-mediated ligand-recognition and the MIRR-triggered signaling cascades are believed to be among the best-studied in biology in recent years, at present the spatial organization of the MIRRs, its reorganization in response to ligand binding as well as the molecular mechanisms underlying the initiation of MIRR signaling remain to be elucidated. The central idea of this book is to show that the structural similarity of the MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms and furthermore, provides the basis for existing and future therapeutic strategies targeting MIRRs. This book intends to assemble reviews on the progress in defining and controlling the spatiotemporal organization of key events in immune cell activation.Improved understanding of MIRR-mediated signaling has a number of potential practical applications, from the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Advances in Experimental Medicine and Biology, Volume 640: Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease. To get started finding Advances in Experimental Medicine and Biology, Volume 640: Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease, you are right to find our website which has a comprehensive collection of manuals listed.
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ISBN: 0387097880

Description: Multichain Immune Recognition Receptors (MIRRs) represent a family of surface receptors expressed on different cells of the hematopoetic system and function to transduce signals leading to a variety of biologic responses. These receptors share common structural features, including extracellular ligand-binding domains and intracellular signaling domains carried on separate subunits. Another important feature linking members of the MIRR family is the presence of one or more copies of a cytoplasmic structural module termed the immunoreceptor tyrosine-based activation motif (ITAM). ITAMs consist of conserved sequences of amino acids that contain two appropriately spaced tyrosines (YxxL/Ix6-8YxxL/I; where x denotes non-conserved residues). Following receptor engagement, phosphorylation of ITAM tyrosine residues represents one of the earliest events in the signaling cascade. Although the MIRR-mediated ligand-recognition and the MIRR-triggered signaling cascades are believed to be among the best-studied in biology in recent years, at present the spatial organization of the MIRRs, its reorganization in response to ligand binding as well as the molecular mechanisms underlying the initiation of MIRR signaling remain to be elucidated. The central idea of this book is to show that the structural similarity of the MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms and furthermore, provides the basis for existing and future therapeutic strategies targeting MIRRs. This book intends to assemble reviews on the progress in defining and controlling the spatiotemporal organization of key events in immune cell activation.Improved understanding of MIRR-mediated signaling has a number of potential practical applications, from the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Advances in Experimental Medicine and Biology, Volume 640: Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease. To get started finding Advances in Experimental Medicine and Biology, Volume 640: Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease, you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

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Advances in Experimental Medicine and Biology, Volume 640: Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease

Advances in Experimental Medicine and Biology, Volume 640: Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease

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